| |
Total (column %)
|
Registration
|
Timeliness of registrationa
|
Primary outcome comparisone
|
Primary outcome results
|
|---|
|
Unregistered (%)b
|
Overall chi-squared p value
|
Retrospective (%)c
|
Overall chi-squared p value
|
Retrospective after initial primary outcome ascertainment (%)c, d
|
Overall chi-squared p value
|
Non-discordant (%)c
|
Overall chi-squared p value
|
Favorable (%)f
|
Overall chi-squared p value
|
|---|
|
Total
|
486 (100)
|
47 (9.7)
|
< 0.001
|
99 (22.6)
|
0.21
|
67 (15.3)
|
0.004
|
249 (56.7)
|
.049
|
282 (66.4)
|
0.11
|
|
AJP
|
52 (10.7)
|
6 (11.5)
|
15 (32.6)
|
14 (30.4)
|
17 (37.0)
|
45 (86.5)
|
|
AJRCCM
|
51 (10.5)
|
4 (7.8)
|
7 (14.9)
|
7 (14.9)
|
28 (59.6)
|
29 (60.4)
|
|
AON
|
37 (7.6)
|
16 (43.2)
|
5 (23.8)
|
3 (14.3)
|
8 (38.1)
|
24 (72.7)
|
|
Blood
|
52 (10.7)
|
0 (0.0)
|
9 (17.3)
|
4 (7.7)
|
26 (50.0)
|
23 (60.5)
|
|
Gast.
|
53 (10.9)
|
1 (1.9)
|
7 (13.4)
|
7 (13.5)
|
30 (57.7)
|
30 (68.2)
|
|
Hep.
|
50 (10.3)
|
7 (14.0)
|
9 (20.9)
|
4 (9.3)
|
27 (62.8)
|
21 (60.0)
|
|
JACI
|
51 (10.5)
|
7 (13.7)
|
12 (27.3)
|
5 (11.4)
|
25 (56.8)
|
27 (64.3)
|
|
JCO
|
51 (10.5)
|
0 (0.0)
|
10 (19.6)
|
4 (7.8)
|
35 (68.6)
|
28 (57.1)
|
|
JACC
|
50 (10.3)
|
4 (8.0)
|
16 (34.8)
|
15 (32.6)
|
34 (73.9)
|
30 (66.7)
|
|
JASN
|
39 (8.0)
|
2 (5.1)
|
9 (24.3)
|
4 (10.8)
|
19 (51.4)
|
25 (64.1)
|
- aAmong 439 registered trials, we could not determine timeliness of registration for 2 (1 published in Gastroenterology and the other in JCO), as enrollment start date was missing from registrations. We excluded these 2 trials from analyses of association pertaining to overall timeliness of registration and timeliness of registration relative to initial primary outcome ascertainment
- bPercentages are expressed as fraction of total trials in each row
- cPercentages are expressed as fraction of registered trials in each row
- dDue to the nature of the primary outcome (i.e., median survival), we could not determine if retrospective registration occurred after initial primary outcome ascertainment in 8 cases: 1 in Blood; 1 in Hepatology; 2 in JACI; and 4 in JCO. These trials were excluded from analyses of association pertaining to timeliness of registration relative to initial primary outcome ascertainment
- e26 of 439 registered trials did not have a primary outcome designated in their publication and were, therefore, excluded from analyses of association pertaining to primary outcome concordance
- fPercentages are expressed as fraction of trials in each journal for which primary outcome favorability could be judged (row totals not shown)
- Abbreviations: AJP American Journal of Psychiatry, AJRCCM American Journal of Respiratory and Critical Care Medicine, AON Annals of Neurology, Gast. Gastroenterology, Hep. Hepatology, JACI Journal of Allergy and Clinical Immunology, JCO Journal of Clinical Oncology, JACC Journal of the American College of Cardiology, JASN Journal of the American Society of Nephrology
