Fig. 1

Construction of study sample comprising the 50 most recent clinical trial publications appearing in each of ten high-impact US medical specialty society journals between 1 January 2010 and 31 December 2015. aIncludes post hoc analyses, exploratory analyses, analyses of secondary outcomes, long-term follow-up, interim analyses, pooled analyses, extension trials, and studies utilizing data derived from clinical trials. bIncludes case reports, case series, modeling studies, and twin studies