Table 1 Schematics of hypothetical full and partial factorial designs
From: Partial factorial trials: comparing methods for statistical analysis and economic evaluation
Full factorial trial (n = 400) | ||||||
Placebo of A | Drug A | Total | ||||
Placebo of B | 100 pts. (00) | 100 pts. (a0) | 200 pts | |||
Drug B | 100 pts. (0b) | 100 pts. (ab) | 200 pts | |||
Total | 200 pts | 200 pts | ||||
Partial factorial trial (n = 400) | ||||||
Randomised in comparison A | Not randomised in comparison A | Total | ||||
Placebo of A | Drug A | Did not have A | Received A | |||
Randomised in comparison B | Placebo of B | 40 pts. (00) | 40 pts. (a0) | 30 pts. (−0) | 40 pts. (+ 0) | 150 pts |
Drug B | 40 pts. (0b) | 40 pts. (ab) | 28 pts. (−b) | 42 pts. (+b) | 150 pts | |
Not randomised in comparison B | Did not have B | 10 pts. (0–) | 11 pts. (a–) | |||
Received B | 40 pts. (0+) | 39 pts. (a+) | ||||
Total | 130 pts | 130 pts | ||||