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Table 3 Ten lessons learnt for consideration in a future trial

From: Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)

Contracts 1 Early agreement between sponsor, NHS sites and university centres about how the contracting process should be arranged with model research collaboration agreements
Site set-up 2 Early discussions about site requirements using a site feasibility questionnaire
3 Recruitment of a dedicated research physiotherapist (or other personnel) at each site
Treatment acceptability 4 Establish if the proposed treatment is acceptable to all principal investigators
  5 Determine if the proposed treatment is acceptable to sciatica patients, using further qualitative research
Recruitment 6 Simplify two-stage recruitment process
7 Use telephone or text reminders two weeks after patients receive letter of invitation
8 Use of lay advocates already recruited into the study
9 Recruitment during real-time GP consultations
Feasibility study 10 Feasibility study testing several key recruitment methods
  1. GP General practitioner, NHS National Health Service