AST/ALT | Alkaline phosphatase | Dose adjustment |
---|---|---|
< 1.5 × upper normal limit (UNL) | < 5 × UNL | No change |
> 1.5 to < 2.5 × UNL | < 2.5 × UNL | No change |
> 2.5 to < 5 × UNL | < 2.5 × UNL | Taxol reduction from 135 to 120 mg/m2 |
> 1.5 to < 5 × UNL | > 2.5 to < 5 × UNL | Taxol reduction from 135 to 120 mg/m2 |
>  5 × UNL | > 5 × UNL | Drug delayed for a maximum of 2 weeks; if taxol reduction from 135 to 120 mg/m2 is not achieved, treat patient with chemotherapy |