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Table 1 RTOG acute reaction grading

From: Combined pretreatment with 18F-FDG PET/CT and Comet assay guides the concurrent chemoradiotherapy of locally advanced cervical cancer: study protocol for a randomized controlled trial

  Grade 1 Grade 2 Grade 3 Grade 4
Skin Follicular, faint or dull erythema / epilation / dry desquamation / decreased sweating Tender or bright erythema, patchy moist desquamation /moderate edema Confluent,moist desquamation other than skin folds, pitting edema Ulceration, hemorrhage,necrosis
Genitourinary Frequency of urination or nocturia is twice as much as before / dysuria, urgency not requiring medication Frequency of urination or nocturia that is less frequent than every hour. Dysuria, urgency, bladder spasm requiring local anesthetic (e.g., Pyridium) Frequency with urgency and nocturia hourly or morefrequently/dysuria, pelvis pain or bladder spasm requiring regular, frequent narcotic/gross hematuria with/ without clot passage Hematuria requiring transfusion/acute bladder obstruction not secondary to clot passage, ulceration, or necrosis
Lower G.I. including pelvis Increased frequency or change in quality of bowel habits not requiring medication / rectal discomfort not requiring analgesics Diarrhea requiring parasympatholytic drugs/ mucous discharge not necessitating sanitary pads/rectal or abdominal pain requiring analgesics Diarrhea requiring parenteral support/severe mucous or blood discharge necessitating sanitary pads/abdominal distention Acute or subacute obstruction, fistula or perforation; GI bleeding requiring transfusion; abdominal pain or tenesmus requiring tube decompression or bowel diversion