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Table 2 Systemic combination therapy for eradication of MRSA carriage in complicated carriage according to the Dutch MRSA guideline [10]

From: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition: study protocol for a randomized multicenter trial

Dutch MRSA guideline

Antibiotic 1

Antibiotic 2

Recommended

Sulfamethoxazole/Trimethoprim 960 mg twice daily

or

Doxycycline 200 mg once daily

Rifampicin 600 mg twice daily

Alternativeɑ

Clindamycin 600 mg thrice daily

or

Clarithromycin (or another macrolide) 500 mg twice daily

or

Ciprofloxacin (or another quinolone) 750 mg twice daily

or

Fusidic acid 500 mg thrice daily

or

Linezolid 600 mg twice daily

Fusidic acid 500 mg thrice daily

  1. All treatments are prescribed preferably by means of tablets or capsules. The dosages in this table are the recommended dosages for an adult patient of about 70 kg. Combination therapy will be used because of better effectiveness and a decreased chance of developing resistance
  2. É‘Alternative options should only be used when there is a contraindication (e.g., in vitro resistance, intolerance) for the recommended options
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