Secondary outcome measure | Data collection instrument or method |
---|---|
Incidence of S. aureus infections | (S)AE forms every 3Â months |
Overall incidence of infections | (S)AE forms every 3Â months |
Mortality | Data from electronic patient file |
Long-term antimicrobial resistance | Culture results every 6Â months and NGS |
Number of catheter removals | Data from electronic patient file |
Time to first catheter-related infection | (S)AE forms every 3Â months and data from electronic patient file |
Successful S. aureus eradication per body site | Culture results |
Relapse rate of S. aureus carriage | Culture results and NGS |
Transmission routes | Caregivers culture results and NGS |
S. aureus transmission routes | NGS |
Adverse events | (S)AE forms every 3Â months |
Predictors for infections and treatment failure or success | Binominal regression analysis |
Patient compliance | Medication files, counting pills, trial-specific medication diary, modified Morisky Medication adherence questionnaire |
Generic health related quality of life | EuroQol 5 dimension, 5 levels questionnaire (EQ5D-5Â L) |
Treatment satisfaction | TSQM vII questionnaire |
Healthcare related costs | iMCQ questionnaire |