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Table 1 Study exclusion criteria

From: Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial

Preoperative left ventricular ejection fraction less than 30%
Emergent procedure
Isolated aortic surgery
Pre-existing cognitive impairment
Parkinson’s disease
Alzheimer’s disease
Recent seizures (<3 months)
Prophylactic medications for cognitive decline
Serum creatinine greater than 2 mg/dL
Liver dysfunction (liver enzymes more than four times the baseline or history and exam suggestive of jaundice)
Active (in the past year) history of alcohol or drug abuse (>10 drinks per week)
Hypersensitivity to any of the study medications
Non–English-speaking (inability to complete the cognitive assessments)