Table 1 Overview of secondary outcomes

Secondary objectives

To evaluate the predictive value of a preceding aerobic and coordination training for transfer of cognitive training gains in healthy older adults (HOA)

To evaluate the predictive value of baseline physical activity on transfer in HOA. Baseline physical activity will be measured by a 1-week actigraphy and the Global Physical Activity Questionnaire (see “Measures” section below).

To evaluate the predictive value of brain vascular lesion (as determined by T2-weighted magnetic resonance imaging (MRI), cortical amyloid burden (as determined by positron-emission tomography), higher default mode network activity (as determined by resting state functional MRI (fMRI) for transfer of cognitive training gains in HOA

To model and analyze multimodal, high-dimensional datasets with respect to transfer prediction and to build a robust individual index of transfer likelihood