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Table 4 Power and sample size justification

From: Dietary approaches to treat MS-related fatigue: comparing the modified Paleolithic (Wahls Elimination) and low saturated fat (Swank) diets on perceived fatigue in persons with relapsing-remitting multiple sclerosis: study protocol for a randomized controlled trial

Variable Within Study Groups Between Study Groups at Last Visit
MMCD SD Correlation MMCD SD Group A SD Group B
Power is ≥0.85 for the primary outcome
 FSS-9 1.2–2.0 1.1–1.4 0.6 0.7 [35] 0.9 1.1
Power is ≥0.90 for secondary outcomes
 MSQOL-54       
 PHC 11.5 16.0 0.6 17.0 17.0 19.0
 MHC 12.0 17.0 0.5 18.0 18.0 19.0
 6 min walk test 35 50.0 0.5 45.0 45.0 50.0
 Timed 25 ft walk 2.9 4.0 0.5 4.0 4.0 4.3
 9 hole peg test 5.5 8.0 0.5 8.0 8.1 8.3
 PASATa 4.2 6.0 0.5 5.8 6.0 6.3
  1. Abbreviations: FSS Fatigue Severity Scale, MSQOL-54 Multiple Sclerosis Quality of Life 54, PHC MSQOL-54 physical health composite score, MHC MSQOL-54 mentalhealth composite score, PASAT Paced Auditory Serial Addition Test, MMCD Minimun Mean Clinical Difference
  2. aPower and sample size calculations based on PASAT. Per NMSS, SDMT-O replaces the PASAT measure in this study