Table 3 Outcomes: change after 12-week intervention and 12 weeks of sustained intervention relative to observation period

Primary outcome measure:

 1. Perceived fatigue assessed by FSS.

Secondary outcome measures:

 1. Perceived fatigue assessed by MFIS;

 2. Perceived fatigue assessed by FSMCF;

 3. Gait speed assessed by T25FW;

 4. Distance walked assessed by 6MWT;

 5. Speed of task completion in 9HPT;

 6. Number of correct responses assessed by SDMT-O;

 7. Quality of life as measured by MSQOL-54;

 8. Quality of life as measured by SF-36;

 9. MSISv2 score;

 10. Anxiety and depression as measured by HADS;

 11. Physical activity (average daily steps and average minutes spent sedentary, light intensity physical activity, moderate intensity physical activity and vigorous intensity physical activity) and sleep (total sleep time, sleep efficiency) as measured by the accelerometer;

 12. Sleep quality as measured by PSQI;

 13. Stress as measured by PSS-10;

 14. Physical activity as assessed by IPAQ-L;

 15. Cognitive performance as measured by PDQ;

 16. Change in mood as measured by the MHI.

 17. Nutritional adequacy of the diet as measured by food frequency questionnaire (FFQ) and food records;

 18. Changes in blood biomarkers (insulin, glucose, hemoglobin A1c, lipids including HDL, vitamin K, vitamin D, calcium, vitamin B₁₂, folate, homocysteine, complete blood count with differential, Cardio IQ® [fatty acid levels]).