A dose-response study of aerobic training for oxygen uptake, oxidative stress and cardiac autonomic function in type 2 diabetes mellitus: study protocol for a randomized controlled trial

Table 2 Outcomes and criterion measures

Primary Outcomes
Oxygen Uptake Response
a) Maximal Response	Peak oxygen consumption
b) Dynamic Response	Time constant of rise to steady state (“on” kinetics) Time constant of recovery from steady state (“off” kinetics)
Oxidative stress
a) Antioxidant enzymes	Catalase Superoxide dismutase Glutathione peroxidase
b) Reactive species	Nitric oxide
Cardiac Autonomic Function
a) Resting	Heart Rate Variability Time-domain indices: AvgNN, SDNN, RMSSD, pNN50 Frequency-domain indices: Total power, LF, HF, LF: HF ratio
b) Post-exercise	Heart rate recovery at 1 (HRR_1min) and 2 min (HRR_2min)
Secondary Outcomes
Cardiometabolic risk factors
a) Glycemic control	Glycosylated hemoglobin Fasting blood glucose
b) Lipid profile	Total cholesterol High-density Lipoprotein Low-density Lipoprotein Triglycerides
c) Resting blood pressure	Systolic blood pressure Diastolic blood pressure
Body composition
a) Body fat (%)	Percent body fat derived from sum of skinfolds
b) Central obesity	Waist circumference Waist-Hip ratio

AvgNN Mean of N-N intervals, SDNN Standard deviation of N-N intervals, RMSSD Square root of the mean squared differences between adjacent RR intervals, pNN50 Percentage of interval differences of adjacent RR intervals greater than 50 milliseconds derived from differences between consecutive RR intervals, LF Low frequency power, HF High frequency power, LF/HF ratio Ratio of low and high frequency power

ISSN: 1745-6215