Skip to main content

Table 1 Determination of target population for an RCT on the use of corticosteroids for paediatric septic shock

From: Contributions of a survey and retrospective cohort study to the planning of a randomised controlled trial of corticosteroids in the treatment of paediatric septic shock

Population

60 cm3/kg of fluid + 1 low dose of vasoactive drug

60 cm3/kg of fluid + 1 high dose of vasoactive drug

60 cm3/kg of fluid + ≥2 types of vasoactive drug

P value

Physicians who administer corticosteroids % (N)

8.7 (2/23)

52.2 (12/23)

95.7 (22/23)

< 0.0001

Patients who received corticosteroids % (N)a

6.4 (5/81)

23.9 (19/81)

50.8 (41/81)

<  0.0001

Physicians who would randomize patients into an RCT % (N)

65.2 (15/23)

69.6 (16/23)

34.8 (8/23)

0.035

Physicians who would prescribe open-label steroids % (N)

4.3 (1/23)

30.4 (7/23)

87.0 (20/23)

< 0.0001

  1. aData from the retrospective cohort study. All other data were from the survey
  2. RCT randomised controlled trial