Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial

Table 3 Study phases and visit schedules for the intensive lifestyle intervention

Phase	Timeline	Individual Visit Schedule
1. Low Energy Diet + Physical Activity	Weeks 1–12	Visit every 2 weeks Dietitian (30 min/visit) Exercise trainer (30 min/visit)
1. Low Energy Diet + Physical Activity	Weeks 1–12	Physician review at baseline and on completion of Phase 1
2. Partial Low Energy Diet + Physical Activity	Weeks 13–24	Visit every 2 weeks Dietitian (30 min/visit) Exercise trainer (30 min/visit)
2. Partial Low Energy Diet + Physical Activity	Weeks 13–24	Physician review on completion of Phase 2
3. Lifestyle change	Weeks 25–48	Visit every 4 weeks Dietitian (30 min/visit) Exercise trainer (30 min/visit)
3. Lifestyle change	Weeks 25–48	Physician review at 3-month and on completion of Phase 3
4. Follow-up	Weeks 49–96	3 monthly visits for follow-up Dietitian (30 min/visit) Exercise trainer (30 min/visit)
4. Follow-up	Weeks 49–96	Physician review at 3-month intervals and completion of Phase 4
5. Post Study	Minimum 2 years post-study	Review by weight management service Collection of data via electronic medical records

ISSN: 1745-6215