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Table 2 Fundamental scheme of the hybrid financial management model utilized by D2d for a typical site that projected to enroll (i.e., randomize) 125 participants

From: Financial management of large, multi-center trials in a challenging funding milieu

  Year 1 Year 2 Year 3 Year 4 Year 5 Total
Personnel (effort and fringe benefits) 178,135 183,100 183,100 137,171 137,171  
Non-personnel 44,534 65,586 60,208 22,043 12,297  
Total proposed budget 222,669 248,686 243,308 159,214 149,468 1,023,345
Core
 Proposed Corea 89,068 91,550 91,550 68,586 68,586 409,339
 Actual Coreb 89,068 99,474 99,474 99,474 21,848 409,339
Performance-Based Payments
 PBP amount per enrolled participant: 4912 614,007
  1. Amounts shown in US$; numbers include directs and 53% indirect rate. The scheme is flexible both from year to year and from site to site, while maintaining consistency
  2. aProposed Core was defined at the start of the study as 50% of annual personnel costs
  3. bActual Core varied from year to year (see text) while the total amount over 5 years did not exceed the total proposed Core (i.e., US$409,339)