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Table 2 Number of tablets to be taken once daily based on WHO guidelinesa

From: Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial

Weight bands

Intensive phase

Continuation phase

50H, 75R, 150Z

100Eb

50H, 75R

3.0–3.9 kg

0.75

0.75

0.75

4.0–7.9 kg

1

1

1

8.0–11.9 kg

2

2

2

12.0–15.9 kg

3

3

3

16.0–24.9 kg

4

4

4

≥ 25.0 kg

Adult formulation and doses

Adult formulation and doses

Adult formulation and doses

  1. R rifampicin, H isoniazid, Z pyrazinamide, E ethambutol
  2. aH: 10 mg/kg (range 7–15 mg/kg) to a maximum dose 300 mg/day; R: 15 mg/kg (range 10–20 mg/kg) to a maximum dose 600 mg/day; Z: 35 mg/kg (30–40 mg/kg); E: 20 mg/kg (15-25 mg/kg)
  3. b100E: additional, separate, single-dose E 100-mg tablets, where this is given as part of local practice, are provided for the intensive phase
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Trials

ISSN: 1745-6215