Table 1 Eligibility criteria for participation in the REACT study and the magnetic resonance imaging (MRI) sub-study
Inclusion criteria | Aged 65 years or older and not in full-time employment Planning to reside in the target area (Bath/Bristol, Devon, Birmingham) for at least 24Â months Score between 4 and 9 (inclusive) on the Short Physical Performance Battery (SPPB) |
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Exclusion criteria | Self-reported inability to walk across a room without a walker or the help of another person Existing major mobility limitation (defined as SPPB of 3 or less, or unable to complete the 4-m walk component of SPPB) Living in residential or nursing care Inability to attend the REACT physical activity sessions as scheduled A documented or patient-reported medical condition that would preclude participation, including: • Arthritis so severe it would prevent participation in physical activity • Parkinson’s disease or diagnosed dementia • Any terminal illness • Lung disease requiring use of orally administered corticosteroids or supplemental oxygen • Severe kidney disease requiring dialysis • Severe heart disease that would prevent participation in physical activity (e.g. chest pain when walking 100 or 200 yards or up a flight of stairs) • Implanted cardiac defibrillator • Cardiac arrest which required resuscitation • Severe uncontrolled psychiatric illness • Currently receiving radiation therapy or chemotherapy treatment for cancer • Awaiting knee or hip surgery • Major heart surgery (including valve replacement or bypass surgery) in the last 6 months • Unstable heart condition (e.g. uncontrolled arrhythmia, angina, heart failure or hypertension) • Spinal surgery in the last 6 months • Any other clinical condition that the person’s GP or clinician considers would make them unsuitable for participation in a physical activity rehabilitation programme to prevent decline of lower-limb functioning For the MRI sub-study: Contraindications for MRI scanning (assessed using CRIC Bristol Standard Operating Procedure for Screening Subjects for Safety to Scan (Ref MRI Local Rules and Procedures, 2011) History of neurological illness (e.g. stroke) Current treatment for a psychiatric illness Insufficient English to understand what participation entails and provide consent in English |
Temporary exclusion criteria | Heart attack (or myocardial infarction), stroke, spinal surgery, hip fracture, hip or knee replacement within the previous 6 months Currently receiving physical therapy on legs or enrolled in another physical activity research or intervention study |