Table 2 Primary and secondary endpoints
Measurement | Site | Time (months) | |
|---|---|---|---|
Primary endpoints | |||
Δ Bone mineral density | DXA | Total hip Spinal region | 12 |
Secondary endpoints | |||
Δ Bone mineral density | DXA | Total hip Spinal region | 6, 18, and 24 |
Δ Bone microarchitecture | HR-pQCT | Distal radius Distal tibia | 6, 12, 18, and 24 |
Δ Bone biomarkers | P1NP CTX, sclerostin | Serum | 3, 6, 12, 18, and 24 |
Δ Physical biomarkers | TUG SPPB | 3, 6, 12, 18, and 24 | |
Dynamometer | Hand grip | ||
Nottingham power rig | Leg extensor | ||
Δ Quality of life | EQ-5D | 12 and 24 | |
Δ Fear of falling | FES-I | 12 and 24 | |
Physical activity | IPAQ | 0, 12, and 24 | |
Adherence to WBV | Training logbook | Continuously | |
Falls | Falls calendar | Continuously | |