Fig. 1

The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Figure with the schedule of enrollment, interventions, and assessments. BMD bone mineral density; Bone turnover biomarkers procollagen type-1 amino-terminal propeptide, carboxy-terminal type-1 collagen crosslinks, sclerostin; HR-pQCT high-resolution peripheral quantitative computed tomography; FES-I Falls Efficacy Scale International; Functional biomarkers: Short Physical Performance Battery, Timed Up and Go, grip strength, leg extension power; IPAQ International Physical Activity Questionnaire.