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Table 1 Estimated difference in 5-year mortality risk (95% confidence interval) when comparing 0% vs. 100% of follow-up being at least 80% adherent, Coronary Drug Project

From: Improved adherence adjustment in the Coronary Drug Project

Method Unadjusted Standardized by baseline covariates + IP weighting for post-randomization covariates
Censoring when binary adherence level deviates from baseline 9.6 (– 7.0, 28.9) 1.5 (– 11.0, 16.4) 0.01 (– 12.2, 13.2)
Dose-response hazards models
 Quadratic cumulative adherence 6.7 (− 3.2, 16.5) 2.6 (− 5.8, 11.1) 0.2 (− 8.2, 8.6)
 Quadratic cumulative adherence, with time interaction 6.0 (− 5.8, 18.0) 1.6 (− 8.4, 11.6) − 0.7 (− 12.2, 10.7)
 Binary current adherence, plus quadratic cumulative adherence up to previous visit 11.6 (− 1.0, 24.2) 6.4 (− 3.9, 16.8) 4.5 (− 6.3, 15.3)
 Binary current adherence, plus quadratic cumulative adherence up to previous visit, with time interaction 10.3 (− 2.3, 22.9) 4.0 (− 6.0, 14.1) 2.4 (− 9.3, 14.1)