Table 2 Variables, outcome measures and methods of analysis
Variable/outcome | Hypothesis | Outcome measure | Methods of analysis |
|---|---|---|---|
Primary outcome | Intervention improved outcome | Â | Â |
  SPADI change Δt0-t3 |  | Score 0–100 (continuous) | cLMM |
Secondary outcomes | Intervention improved outcome | Â | Â |
  Abd. MVC change Δt0-t3 |  | Nm/kg (continuous) | cLMM |
  Ext. rot. MVC change Δt0-t3 |  | Nm/kg (continuous) | cLMM |
  Abd. total ROM change Δt0-t3 |  | Degrees (continuous) | cLMM |
  Pain last week change Δt0-t3 |  | NRS 0–10 (continuous) | cLMM |
  EQ-5D change Δt0-t3 |  | Index value (continuous) | cLMM |
  Global impression of change, at t3 |  | % much improved/fully recovered (binary) | χ2 test |
 Pain sensitisation Δt1-t3 |  |  |  |
  Temporal Summation of Pain |  | VAS increase (continuous) | cLMM |
  Conditioned Pain Modulation |  | kPa increase (continuous) | cLMM |
  Pain Pressure Threshold |  | kPa (continuous) | cLMM |
 Scapular involvement |  |  |  |
  SAT |  | % positive (binary) | χ2 test |
  SDT |  | % positive (binary) | χ2 test |
Subgroup analyses | Â | Â | Â |
  Scapula involvement (SAT and SDT yes/no) | Dysfunction modifies the effect of intervention | SPADI score, abduction MVC and external rotation MVC (continuous) | cLMM with interaction term |
  Central sensitisation (TS and CPM high vs. low) | CS modifies the effect of intervention | SPADI score, abduction MVC and external rotation MVC (continuous) | cLMM with interaction term |
Sensitivity analyses | Intervention improved outcome | Primary outcome | Â |
  Per protocol analysis |  |  | cLMM |
  Adjusting for baseline |  |  | cLMM |