Table 1 National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme total spend and randomised controlled trial (RCT) spend compared with the burden of disease (Disability-adjusted Life Years; DALYs) mapped to Health Research Classification System (HRCS) health categories

Cancer

48,141,582

43,289,092

18.84

Cardiovascular

36,492,300

32,422,740

11.92

Musculoskeletal

24,978,542

21,728,235

11.53

Mental health

46,745,011

43,758,644

9.83

Neurological

27,610,923

26,963,249

7.99

Injuries and Accidents

21,045,089

19,834,241

6.33

Respiratory

19,322,359

14,646,317

6.12

Oral and Gastrointestinal

16,654,803

14,152,800

5.79

Stroke

15,093,925

14,841,635

3.84

Infection

34,490,269

30,806,401

3.58

Renal and Urogenital

26,762,773

23,925,063

2.66

Ear

1,947,835

1,243,473

2.31

Skin

11,626,036

11,527,412

2.16

Blood

1,178,448

1,097,847

1.80

Metabolic and Endocrine

8,287,045

6,602,431

1.79

Reproductive health and Childbirth

29,248,437

26,391,283

1.45

Congenital disorders

1,928,151

1,463,336

1.35

Eye

14,971,063

10,276,840

0.89

Inflammatory and Immune

1,069,161

1,069,161

0.16

Other

994,430

994,430

0.08

Generic health relevance

8,623,682

7,281,761

0.00

Total

397,211,864

354,316,391

100