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Table 1 Description of data collection instruments used in ADMET 2

From: The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial

Instrument Domains measured Scoring Administration
A. Apathy
 Modified AD Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC) Change in apathy Seven-point scale where 1 is “very much improved” and 7 is “very much worse”; a rating of 4 being “no change” Based on interview with caregiver by independent, skilled, and experienced clinician
 Neuropsychiatric Inventory (NPI) Frequency and severity of neuropsychiatric symptom (apathy, agitation, delusions, hallucinations, depression, euphoria, aberrant motor behavior, irritability, disinhibition, anxiety, sleeping, and eating disorders) Scores determined by multiplying frequency (scored from 1 to 4) and severity (scored from 1 to 3) with caregiver distress (scored 1 to 5) and adding caregiver distress (scored 1 to 5); total score is sum of the score for each of the 12 (range is from 0 to 144). Higher scores indicate greater frequency and severity of symptoms Interview with caregiver by clinician
 Dementia Apathy Interview and Rating (DAIR) Used to discriminate between apathy from lack of interest due to personality traits and evaluates change in motivation, engagement, and emotional response since disease onset Each of 16 items scored from 0 to 3, with apathy score a sum of all items administered, divided by the number of items completed. Total scores range from 0 to 3, with higher scores representing more apathy Interview with caregiver by clinician
B. Function
 Dependence Scale Assesses the degree of dependence or assistance needed by a participant Scored from 0 to 15, with higher scores indicating an increased level of dependence Based on interview with caregiver by clinician
 Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) Measures the functional performance of patients with AD Scale discriminates between the stages of severity of AD, from very mild to severely impaired Based on structured interview of caregiver by clinician
C. Cost-utility
 EuroQol EQ-5D- 5 L Quality of life domains of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression Each domain graded from level 1 (no problems) to level 5 (extreme problems) Interview of participant and/or caregiver by clinician
 Resource Utilization in Dementia-Lite (RUD-Lite) Assesses resource utilization and includes questions on accommodation, informal care, community care, and hospitalizations Presence or absence of resource use Interview of participant and/or caregiver by clinician
D. Cognition
 Mini-Mental State Exam (MMSE) General cognition Scored from 0 to 30, with higher scores indicating higher cognitive functioning. Administered by trained interviewer to participant
 Hopkins Verbal Learning Test – Revised (HVLT-R) Cognition: verbal learning, recognition, and delayed recall Scored from 0 to 12, with higher scores indicating better performance Administered by trained interviewer to participant
 Digit Span: the Wechsler Adult Intelligence Scale–Revised Digit Span sub-test Cognition: auditory attention and working memory Separate scores are obtained for spans read forwards and backward from 0 to 9 for the number of digits correctly identified and for the longest span that is recalled. Administered by trained interviewer to participant
 Trail Making Tests (A and B) Cognition: attention, executive function, and visuo-motor tracking Time taken to complete the test with shorter time indicating higher cognitive functioning Administered by trained interviewer to participant
 Action Verbal Fluency Test from the Parkinson’s Disease–Cognitive Rating Scale Cognition: executive function, working memory, and information processing speed Score is the total number of unique verbs, with higher counts indicating less cognitive impairment. Administered by trained interviewer to participant
 Category Fluency Task-Animal Naming Cognition: executive function, working memory, set shifting, and executive control Scores are the number of animals verbalized, with higher counts indicating less cognitive impairment Administered by trained interviewer to participant
 Short Boston Naming Test Cognition: expressive language The minimum score is 0 and the maximum score is 15. Higher scores indicate better control of expressive language Administered by trained interviewer to participant
  1. AD Alzheimer’s disease