Instrument | Domains measured | Scoring | Administration |
---|---|---|---|
A. Apathy | |||
Modified AD Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC) | Change in apathy | Seven-point scale where 1 is “very much improved” and 7 is “very much worse”; a rating of 4 being “no change” | Based on interview with caregiver by independent, skilled, and experienced clinician |
Neuropsychiatric Inventory (NPI) | Frequency and severity of neuropsychiatric symptom (apathy, agitation, delusions, hallucinations, depression, euphoria, aberrant motor behavior, irritability, disinhibition, anxiety, sleeping, and eating disorders) | Scores determined by multiplying frequency (scored from 1 to 4) and severity (scored from 1 to 3) with caregiver distress (scored 1 to 5) and adding caregiver distress (scored 1 to 5); total score is sum of the score for each of the 12 (range is from 0 to 144). Higher scores indicate greater frequency and severity of symptoms | Interview with caregiver by clinician |
Dementia Apathy Interview and Rating (DAIR) | Used to discriminate between apathy from lack of interest due to personality traits and evaluates change in motivation, engagement, and emotional response since disease onset | Each of 16 items scored from 0 to 3, with apathy score a sum of all items administered, divided by the number of items completed. Total scores range from 0 to 3, with higher scores representing more apathy | Interview with caregiver by clinician |
B. Function | |||
Dependence Scale | Assesses the degree of dependence or assistance needed by a participant | Scored from 0 to 15, with higher scores indicating an increased level of dependence | Based on interview with caregiver by clinician |
Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) | Measures the functional performance of patients with AD | Scale discriminates between the stages of severity of AD, from very mild to severely impaired | Based on structured interview of caregiver by clinician |
C. Cost-utility | |||
EuroQol EQ-5D- 5 L | Quality of life domains of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression | Each domain graded from level 1 (no problems) to level 5 (extreme problems) | Interview of participant and/or caregiver by clinician |
Resource Utilization in Dementia-Lite (RUD-Lite) | Assesses resource utilization and includes questions on accommodation, informal care, community care, and hospitalizations | Presence or absence of resource use | Interview of participant and/or caregiver by clinician |
D. Cognition | |||
Mini-Mental State Exam (MMSE) | General cognition | Scored from 0 to 30, with higher scores indicating higher cognitive functioning. | Administered by trained interviewer to participant |
Hopkins Verbal Learning Test – Revised (HVLT-R) | Cognition: verbal learning, recognition, and delayed recall | Scored from 0 to 12, with higher scores indicating better performance | Administered by trained interviewer to participant |
Digit Span: the Wechsler Adult Intelligence Scale–Revised Digit Span sub-test | Cognition: auditory attention and working memory | Separate scores are obtained for spans read forwards and backward from 0 to 9 for the number of digits correctly identified and for the longest span that is recalled. | Administered by trained interviewer to participant |
Trail Making Tests (A and B) | Cognition: attention, executive function, and visuo-motor tracking | Time taken to complete the test with shorter time indicating higher cognitive functioning | Administered by trained interviewer to participant |
Action Verbal Fluency Test from the Parkinson’s Disease–Cognitive Rating Scale | Cognition: executive function, working memory, and information processing speed | Score is the total number of unique verbs, with higher counts indicating less cognitive impairment. | Administered by trained interviewer to participant |
Category Fluency Task-Animal Naming | Cognition: executive function, working memory, set shifting, and executive control | Scores are the number of animals verbalized, with higher counts indicating less cognitive impairment | Administered by trained interviewer to participant |
Short Boston Naming Test | Cognition: expressive language | The minimum score is 0 and the maximum score is 15. Higher scores indicate better control of expressive language | Administered by trained interviewer to participant |