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Table 4 Symptom-based therapy adjustment (all therapeutic adjustments will be automatically calculated and advised by the e-CRF)

From: A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

Asthma Control (ACQ7) Treatment increased according to Table 5
ACQ7 ≥ 1.5 and ≥ 1 change from baseline score
OR
severe exacerbation since last visit (past 8 weeks at baseline randomisation visit)
Increase therapy 1 step
ACQ7 is 1.0 to < 1.5 OR ACQ ≥ 1.5 and < 1 change from baseline score AND
no severe exacerbation since last study visit (past 8 weeks at baseline randomisation visit)
No change
ACQ7 < 1.0
AND
no severe exacerbation since last study visit (prior 8 weeks at baseline randomisation visit)
Reduce therapy 1 step
  1. All therapeutic adjustments will be automatically calculated and advised by the electronic case report form (e-CRF)
  2. ACQ7 7-item Asthma Control Questionnaire