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Table 1 Eligibility criteria

From: HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial

Inclusion criteria

Exclusion criteria

Age > 18 years

Prior radiotherapy to mandible > 50 Gy

No evidence of cancer recurrence

Condition requiring surgery to mandible:

 Extraction of premolar or molar

 Implant placement

Provision of written informed consent in competent patient

Prior diagnosis of ORN of the mandible

Prior HBO therapy for any indication

Any previous prescription of systemic bisphosphonates, pentoxyphylline or tocopherol

Pregnancy

Contraindications to HBO:

 Lung disease (severe COPD or bullae)

 Middle ear

 Claustrophobia

  1. COPD chronic obstructive pulmonary disease, HBO hyperbaric oxygen, ORN osteoradionecrosis