Inclusion criteria | Exclusion criteria |
---|---|
Age > 18 years Prior radiotherapy to mandible > 50 Gy No evidence of cancer recurrence Condition requiring surgery to mandible:  Extraction of premolar or molar  Implant placement Provision of written informed consent in competent patient | Prior diagnosis of ORN of the mandible Prior HBO therapy for any indication Any previous prescription of systemic bisphosphonates, pentoxyphylline or tocopherol Pregnancy Contraindications to HBO:  Lung disease (severe COPD or bullae)  Middle ear  Claustrophobia |