Table 1 Inclusion criteria

Age: 19–70 years

Screening visit (Visit 1)

 Hypertension in treatment-naïve patients

  140 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg

 Hypertension with treatment, including ACEI/ARB

  130 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg

 eGFR ≥ 30 mL/min/1.73 m² (by MDRD) within the past six months

 Urine protein (within the past six months)

  ACR ≥ 300 mg/g (or mg/day)

  or protein–creatinine ratio ≥ 500 mg/g (or mg/day)

 Type 2 diabetes mellitus (diagnosed > 3 months prior) on medications with

  no changes in medication regimen/dose within the last three months

Baseline visit (Visit 3)

 Hypertension

  140 mmHg ≤ SBP < 180 mmHg and DBP < 110 mmHg

 eGFR ≥ 30 mL/min/1.73 m² (by MDRD)

 Urine protein: ACR ≥ 300 mg/g in spot urine

 Type 2 diabetes without regimen change during placebo run-in period