Variable/outcome | Hypothesis | Outcome measure (unit, scale) | Methods of analysis |
---|---|---|---|
Descriptive statistics (sample characteristics) | Â | Age, weight, height, side of index knee (continuous and dichotomous) | Summary statistics |
Primary analysis | |||
 Primary outcome | |||
1. Change in isometric knee-extensor strength Δt0-t1 | Group 2 < Group 4 Group 4 ≈ Group 6 | Change in Nm/kg (continuous) | Analysis of variance ANOVAa |
Secondary analysis | |||
 Secondary outcomes | |||
2. Change in isometric knee-extensor strength Δt0-t2, Δt0-t3 | Group 2 < Group 4 Group 4 ≈ Group 6 | Change in Nm/kg (continuous) | ANOVAa |
3. Change in Knee Osteoarthritis Outcome Score (KOOS) subscales Δt0-t1, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in questionnaire subscales (continuous) | ANOVAa |
4. Change in Oxford Knee Score (OKS) Δt0-t1, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in questionnaire (continuous) | ANOVAa |
5. Change in 6-Minute Walking Test for distance (6MWT) Δt0-t1, Δt0-t2, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in meters walked (continuous) | ANOVAa |
6. Change in Stair Climb Test (SCT) Δt0-t1, Δt0-t2, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in time used to ascend and descend stairs (continuous) | ANOVAa |
7. Change in current knee pain (Numeric Rank Scale, NRS) Δt0-t1, Δt0-t2, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in NRS 0–10 (continuous) | ANOVAa |
8. Change in knee pain during the last week (Numeric Rank Scale, NRS) Δt0-t1, Δt0-t3 | Group 2 < Group 4 Group 4 > Group 6 | Change in NRS 0–10 (continuous) | ANOVAa |
9 Distribution in need for surgery | Group 2 < Group 4 Group 4 > Group 6 | Yes, don’t know, no | Summary statistics |
 Other outcomes | |||
10. Difference in adherence to intervention between groups | Group 2 > Group 4 Group 4 > Group 6 Group 2 > Group 6 We hypothesize differences between groups in adherence (%) to the training intervention (i.e., higher number of sessions per week, the lower adherence (%)) | Number of sessions, sets, repetitions and time-under-tension | ANOVAa |