Author, citation | Study design | Exposures | Outcome measures | Results | Conclusions |
---|---|---|---|---|---|
Dagdeviren H et al. Arch Gynecol Obstet. 2016;294:911–916 | RCT 256 women | 10 IU IM vs 10 IU in 1 L normal saline IV 1 mL/min infusion after delivery of anterior shoulder | Measured blood loss and occurrence of 1° PPH | No differences in outcomes | Mode of oxytocin administration no significant differences on postpartum blood loss |
E Orhan et al. Int J Gynecol. 2014;127:175–179 | RCT 600 women 150 in each group Group IV divided into IV(A) and (B) Group IM divided into IM(A) and (B) | Group IV- 10 IU oxytocin 1 mL/min Group IM -10 IU oxytocin (A) after delivery of fetus (B) at delivery of anterior shoulder | Measured blood loss Δ Hb + Hct Side effects | Significant differences in Δ Hb + Hct in IV(A)group Blood loss slightly lower in this group but not significant difference | Mode and timing of administering oxytocin has no significant effects on blood loss but early IV administration may have beneficial effects |