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Table 1 Studies comparing the effect of IM oxytocin and IV oxytocin on haemorrhage after vaginal delivery

From: Intramuscular oxytocin versus intravenous oxytocin to prevent postpartum haemorrhage at vaginal delivery (LabOR trial): study protocol for a randomised controlled trial

Author, citation

Study design

Exposures

Outcome measures

Results

Conclusions

Dagdeviren H et al.

Arch Gynecol Obstet. 2016;294:911–916

RCT

256 women

10 IU IM vs 10 IU in 1 L normal saline IV 1 mL/min infusion after delivery of anterior shoulder

Measured blood loss and occurrence of 1° PPH

No differences in outcomes

Mode of oxytocin administration no significant differences on postpartum blood loss

E Orhan et al.

Int J Gynecol. 2014;127:175–179

RCT

600 women

150 in each group

Group IV divided into IV(A) and (B) Group IM divided into IM(A) and (B)

Group IV- 10 IU oxytocin 1 mL/min

Group IM -10 IU oxytocin

(A) after delivery of fetus

(B) at delivery of anterior shoulder

Measured blood loss

Δ Hb + Hct

Side effects

Significant differences in Δ Hb

+ Hct in IV(A)group

Blood loss slightly lower in this group but not significant difference

Mode and timing of administering oxytocin has no significant effects on blood loss but early IV administration may have beneficial effects