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Table 3 Treatment differences on baseline covariates by intravenously administered alteplase status at interim analysis (N = 316)

From: Minimal sufficient balance randomization for sequential randomized controlled trial designs: results from the ESCAPE trial

Baseline covariates

IV alteplase (n = 237)

Without IV alteplase (n = 78)

Treatment (n = 120)

Control (n = 117)

p value

Treatment (n = 45)

Control (n = 33)

p value

Age (mean, SD)

69.16 (12.32)

68.43 (14.89)

0.68

69.76 (16.31)

69.45 (13.19)

0.93

NIHSS score (mean, SD)

16.38 (5.35)

16.69 (5.75)

0.66

16.93 (5.60)

15.73 (5.43)

0.34

Sex (% female)

50.00%

51.28%

0.844

57.78%

57.58%

0.99

ASPECTS score (% (8–10))

66.67%

70.09%

0.572

60.00%

72.73%

0.24

Baseline occlusion location (% MCA M1)

73.33%

72.65%

0.906

73.33%

75.76%

0.81

  1. ASPECTS Alberta Stroke Program Early CT score, MCA M1 M1 segment of middle cerebral artery, NIHSS National Institute of Health Stroke Severity Scale, SD standard deviation, IV intravenously administered