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Table 1 Pairwise correlation (Pearson’s rho) among the six baseline covariates used in the minimal sufficient balance randomization procedure

From: Minimal sufficient balance randomization for sequential randomized controlled trial designs: results from the ESCAPE trial

 

Age (years)

Sex

NIHSS score

ASPECTS score

Occlusion location

Alteplase (tPA)

Continuous variable

Binary variable (male/female)

Continuous integer variable (score from 6 to 42)

Binary variable (good score 8–10 vs. moderate score 6–7)

Binary variable (MCA vs. ICA)

Binary variable (true/false)

Age

1.000

     

Sex

0.1587

1.000

    

NIHSS score

0.2125

−0.0141

1.000

   

ASPECTS score

0.1125

0.0330

−0.1474

1.000

  

Occlusion location

0.0660

0.0144

− 0.2398

0.0276

1.000

 

Alteplase (tPA)

− 0.0394

− 0.0610

0.0022

0.0274

− 0.0133

1.000

  1. NIHSS National Institutes of Health Stroke Severity Scale, ASPECTS Alberta Stroke Program Early CT score, tPA tissue plasminogen activator, MCA middle cerebral artery, ICA internal carotid artery
  2. These six covariates were chosen a priori because they are known key prognostic variables after acute stroke