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Table 2 The sample size estimates for the PANDA trial with a variety of assumptions

From: A randomised controlled trial assessing the severity and duration of depressive symptoms associated with a clinically significant response to sertraline versus placebo, in people presenting to primary care with depression (PANDA trial): study protocol for a randomised controlled trial

Percentage point reduction Natural log of reduction SD estimate Total sample size Allowing for 10% attrition
11 −0.117 0.34 366 407
14 −0.150 0.34 216 240
11 −0.117 0.4 492 547
14 −0.150 0.4 300 333