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Table 1 The Berlin ARDS definition [1]

From: Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial

Characteristic

Mild ARDS

Moderate ARDS

Severe ARDS

Timing

Acute onset within 1 week of a known clinical insult or new or worsening respiratory symptoms

Hypoxemia

PaO2/FiO2

> 200– ≤ 300 mmHg

with PEEP or CPAP ≥ 5 cmH2O

PaO2/FiO2

> 100– ≤ 200 mmHg

with PEEP ≥ 5 cmH2O

PaO2/FiO2

≤ 100 mmHg

with PEEP ≥ 5 cmH2O

Origin of edema

Respiratory failure associated with known ARDS risk factors and not fully explained by cardiac failure or fluid overload. An objective assessment of cardiac failure or fluid overload is needed if no ARDS risk factors are present

Radiological abnormalities (chest X-ray or CT scan)

Bilateral opacities not fully explained by effusions, nodules, masses or lobar/lung collapse

  1. ARDS acute respiratory distress syndrome, CPAP continuous positive airway pressure, CT computed tomography, PaO 2 /FiO 2 partial pressure of oxygen/fraction of inspired oxygen, PEEP positive end-expiratory pressure
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ISSN: 1745-6215