TY - JOUR AU - Fleischmann, C. AU - Thomas-Rueddel, D. O. AU - Hartmann, M. AU - Hartog, C. S. AU - Welte, T. AU - Heublein, S. AU - Dennler, U. AU - Reinhart, K. PY - 2016 DA - 2016// TI - Hospital incidence and mortality rates of sepsis JO - Dtsch Arztebl Int VL - 113 ID - Fleischmann2016 ER - TY - JOUR AU - Borovikova, L. V. AU - Ivanova, S. AU - Zhang, M. AU - Yang, H. AU - Botchkina, G. I. AU - Watkins, L. R. AU - Wang, H. AU - Abumrad, N. AU - Eaton, J. W. AU - Tracey, K. J. PY - 2000 DA - 2000// TI - Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin JO - Nature VL - 405 UR - https://doi.org/10.1038/35013070 DO - 10.1038/35013070 ID - Borovikova2000 ER - TY - JOUR AU - Hofer, S. AU - Eisenbach, C. AU - Lukic, I. K. AU - Schneider, L. AU - Bode, K. AU - Brueckmann, M. AU - Mautner, S. AU - Wente, M. N. AU - Encke, J. AU - Werner, J. PY - 2008 DA - 2008// TI - Pharmacologic cholinesterase inhibition improves survival in experimental sepsis JO - Crit Care Med VL - 36 UR - https://doi.org/10.1097/01.CCM.0B013E31816208B3 DO - 10.1097/01.CCM.0B013E31816208B3 ID - Hofer2008 ER - TY - JOUR AU - Beilin, B. AU - Bessler, H. AU - Papismedov, L. AU - Weinstock, M. AU - Shavit, Y. PY - 2005 DA - 2005// TI - Continuous physostigmine combined with morphine-based patient-controlled analgesia in the postoperative period JO - Acta Anaesthesiol Scand VL - 49 UR - https://doi.org/10.1111/j.1399-6576.2004.00548.x DO - 10.1111/j.1399-6576.2004.00548.x ID - Beilin2005 ER - TY - JOUR AU - Dejager, L. AU - Pinheiro, I. AU - Dejonckheere, E. AU - Libert, C. PY - 2011 DA - 2011// TI - Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? JO - Trends Microbiol VL - 19 UR - https://doi.org/10.1016/j.tim.2011.01.001 DO - 10.1016/j.tim.2011.01.001 ID - Dejager2011 ER - TY - JOUR AU - Triggle, D. J. AU - Mitchell, J. M. AU - Filler, R. PY - 1998 DA - 1998// TI - The pharmacology of physostigmine JO - CNS Drug Rev VL - 4 UR - https://doi.org/10.1111/j.1527-3458.1998.tb00059.x DO - 10.1111/j.1527-3458.1998.tb00059.x ID - Triggle1998 ER - TY - STD TI - Dr. Franz Köhler Chemie GmbH. SmPC (Fachinformation) Anticholium® Injektionslösung. 2011. ID - ref7 ER - TY - JOUR AU - Asthana, S. AU - Raffaele, K. C. AU - Berardi, A. AU - Greig, N. H. AU - Haxby, J. V. AU - Schapiro, M. B. AU - Soncrant, T. T. PY - 1995 DA - 1995// TI - Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine JO - Alzheimer Dis Assoc Disord VL - 9 UR - https://doi.org/10.1097/00002093-199509040-00009 DO - 10.1097/00002093-199509040-00009 ID - Asthana1995 ER - TY - JOUR AU - Furey, M. L. AU - Pietrini, P. AU - Alexander, G. E. AU - Mentis, M. J. AU - Szczepanik, J. AU - Shetty, U. AU - Greig, N. H. AU - Holloway, H. W. AU - Schapiro, M. B. AU - Freo, U. PY - 2000 DA - 2000// TI - Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans JO - Pharmacol Biochem Behav VL - 66 UR - https://doi.org/10.1016/S0091-3057(00)00186-6 DO - 10.1016/S0091-3057(00)00186-6 ID - Furey2000 ER - TY - JOUR AU - Roberts, J. A. AU - Lipman, J. PY - 2009 DA - 2009// TI - Pharmacokinetic issues for antibiotics in the critically ill patient JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e3181961bff DO - 10.1097/CCM.0b013e3181961bff ID - Roberts2009 ER - TY - JOUR AU - Paepe, P. AU - Belpaire, F. M. AU - Buylaert, W. A. PY - 2002 DA - 2002// TI - Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock JO - Clin Pharmacokinet VL - 41 UR - https://doi.org/10.2165/00003088-200241140-00002 DO - 10.2165/00003088-200241140-00002 ID - Paepe2002 ER - TY - JOUR AU - Pinder, N. AU - Zimmermann, J. B. AU - Hofer, S. AU - Brenner, T. AU - Weigand, M. A. AU - Gubbe, U. AU - Hoppe-Tichy, T. AU - Swoboda, S. PY - 2015 DA - 2015// TI - Revival of physostigmine - a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients JO - Clin Chem Lab Med VL - 53 UR - https://doi.org/10.1515/cclm-2014-0834 DO - 10.1515/cclm-2014-0834 ID - Pinder2015 ER - TY - STD TI - Worek F, Baumann M, Pfeiffer B, Aurbek N, Thiermann H. Mobiler cholinesterase-schnelltest zur felddiagnostik einer organophosphat-exposition im vollblut. Wehrmedizinische Monatsschrift. 2011;4. ID - ref13 ER - TY - JOUR AU - Lichtenstern, C. AU - Zimmermann, J. B. AU - Rahbari, N. N. AU - Uhle, F. AU - Kerber, S. AU - Weismuller, K. AU - Hofer, S. AU - Walter, V. AU - Bruckner, T. AU - Weitz, J. AU - Weigand, M. A. PY - 2011 DA - 2011// TI - Patients suffering due to complicated peritonitis may not benefit from splenectomy: clinical data from a retrospective study JO - J Surg Res VL - 167 UR - https://doi.org/10.1016/j.jss.2010.10.021 DO - 10.1016/j.jss.2010.10.021 ID - Lichtenstern2011 ER - TY - JOUR AU - Altman, D. G. AU - Bland, J. M. PY - 1999 DA - 1999// TI - Statistics notes. Treatment allocation in controlled trials: why randomise? JO - BMJ VL - 318 UR - https://doi.org/10.1136/bmj.318.7192.1209 DO - 10.1136/bmj.318.7192.1209 ID - Altman1999 ER - TY - JOUR AU - Reinhart, K. AU - Brunkhorst, F. M. AU - Bone, H. G. AU - Bardutzky, J. AU - Dempfle, C. E. AU - Forst, H. AU - Gastmeier, P. AU - Gerlach, H. AU - Grundling, M. AU - John, S. PY - 2010 DA - 2010// TI - Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinare Vereinigung fur Intensiv- und Notfallmedizin (DIVI)) JO - Ger Med Sci VL - 8 ID - Reinhart2010 ER - TY - STD TI - GCP Ordinance (GCP-Verordnung, GCP-V). 2004. http://www.gesetze-im-internet.de/gcp-v/index.html. Accessed 14 Oct 2016. UR - http://www.gesetze-im-internet.de/gcp-v/index.html ID - ref17 ER - TY - STD TI - ICH E2A: International Conference on Harmonisation Tripartite Guideline: clinical safety data management: definitions and standards for expedited reporting. 1994. https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E2A/Step4/E2A_Guideline.pdf. Accessed 14 Oct 2016. UR - https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E2A/Step4/E2A_Guideline.pdf ID - ref18 ER - TY - STD TI - ICH E6(R1): International Conference on Harmonisation Tripartite Guideline: Good Clinical Practice. 1996. https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6/E6_R1_Guideline.pdf. Accessed 14 Oct 2016. UR - https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6/E6_R1_Guideline.pdf ID - ref19 ER - TY - JOUR PY - 2013 DA - 2013// TI - World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects JO - JAMA VL - 310 UR - https://doi.org/10.1001/jama.2013.281053 DO - 10.1001/jama.2013.281053 ID - ref20 ER - TY - STD TI - Medicinal Products Act (Arzneimittelgesetz, Gesetz über den Verkehr mit Arzneimitteln, AMG). 1976. http://www.gesetze-im-internet.de/amg_1976/index.html. Accessed 14 Oct 2016. UR - http://www.gesetze-im-internet.de/amg_1976/index.html ID - ref21 ER - TY - STD TI - Federal Data Protection Act (Bundesdatenschutzgesetz, BDSG). 1990. https://www.gesetze-im-internet.de/bdsg_1990/index.html. Accessed 14 Oct 2016. UR - https://www.gesetze-im-internet.de/bdsg_1990/index.html ID - ref22 ER - TY - JOUR AU - Paraskeva, A. AU - Papilas, K. AU - Fassoulaki, A. AU - Melemeni, A. AU - Papadopoulos, G. PY - 2002 DA - 2002// TI - Physostigmine does not antagonize sevoflurane anesthesia assessed by bispectral index or enhances recovery JO - Anesth Analg VL - 94 UR - https://doi.org/10.1097/00000539-200203000-00017 DO - 10.1097/00000539-200203000-00017 ID - Paraskeva2002 ER - TY - JOUR AU - Petersson, J. AU - Gordh, T. E. AU - Hartvig, P. AU - Wiklund, L. PY - 1986 DA - 1986// TI - A double-blind trial of the analgesic properties of physostigmine in postoperative patients JO - Acta Anaesthesiol Scand VL - 30 UR - https://doi.org/10.1111/j.1399-6576.1986.tb02414.x DO - 10.1111/j.1399-6576.1986.tb02414.x ID - Petersson1986 ER - TY - JOUR AU - Kesecioglu, J. AU - Rupreht, J. AU - Telci, L. AU - Dzoljic, M. AU - Erdmann, W. PY - 1991 DA - 1991// TI - Effect of aminophylline or physostigmine on recovery from nitrous oxide-enflurane anaesthesia JO - Acta Anaesthesiol Scand VL - 35 UR - https://doi.org/10.1111/j.1399-6576.1991.tb03359.x DO - 10.1111/j.1399-6576.1991.tb03359.x ID - Kesecioglu1991 ER - TY - JOUR AU - Paraskeva, A. AU - Staikou, C. AU - Diamadis, M. AU - Siafaka, I. AU - Fassoulaki, A. PY - 2005 DA - 2005// TI - Anesthesia with 1.5 minimum alveolar concentration sevoflurane is not altered by physostigmine as measured by bispectral and clinical indices JO - J Clin Anesth VL - 17 UR - https://doi.org/10.1016/j.jclinane.2005.03.005 DO - 10.1016/j.jclinane.2005.03.005 ID - Paraskeva2005 ER - TY - JOUR AU - Rohm, K. D. AU - Riechmann, J. AU - Boldt, J. AU - Schollhorn, T. AU - Piper, S. N. PY - 2007 DA - 2007// TI - Do patients profit from physostigmine in recovery from desflurane anaesthesia? JO - Acta Anaesthesiol Scand VL - 51 UR - https://doi.org/10.1111/j.1399-6576.2006.01238.x DO - 10.1111/j.1399-6576.2006.01238.x ID - Rohm2007 ER - TY - STD TI - International Committee of Medical Journal Editors (ICMJE) Recommendations: Defining the Role of Authors and Contributors. http://www.icmje.org/recommendations/browse/roles-and-responsibilities/defining-the-role-of-authors-and-contributors.html. Accessed 14 Oct 2016. UR - http://www.icmje.org/recommendations/browse/roles-and-responsibilities/defining-the-role-of-authors-and-contributors.html ID - ref28 ER - TY - JOUR AU - Steiner, T. AU - Walter-Sack, I. AU - Taupitz, J. AU - Hacke, W. AU - Strowitzki, T. PY - 2008 DA - 2008// TI - Ethical and legal aspects of including patients unable to consent in acute therapy studies. Example of a medication study for the treatment of intracerebral hemorrhage--the Heidelberg procedure JO - Dtsch Med Wochenschr VL - 133 UR - https://doi.org/10.1055/s-2008-1075648 DO - 10.1055/s-2008-1075648 ID - Steiner2008 ER -