Willingness to participate in pragmatic dialysis trials: the importance of physician decisional autonomy and consent approach

Table 2 Bivariate associations between trial attributes and patients’ willingness to have clinic participate

Attribute	Willing to participate^a, number^b (percentage)	OR (95% CI)	P value
Autonomy
Low	635 (79)	1.00	0.13
High	617 (77)	0.81 (0.61, 1.06)	0.13
Burden
Low	641 (80)	1.00	0.06
High	611 (76)	0.70 (0.48, 1.01)	0.06
Consent
Opt-in	336 (84)	1.00	<0.001
Opt-out	333 (82)	0.88 (0.49, 1.57)
Notification-only	323 (81)	0.68 (0.38, 1.23)
No-notification	260 (66)	0.19 (0.10, 0.34)

^aWillingness to participate was defined as the “definitely willing” or “probably willing” categories combined
^bDenominators differ for each attribute because of the 1600 total randomized controlled trial scenarios answered (200 patients × 8 scenarios), each level of burden and autonomy was included in 50% of the scenarios (N = 800), whereas the four levels of consent were each included in 25% of the scenarios (N = 400)

ISSN: 1745-6215