A series of N-of-1 trials to assess the therapeutic interchangeability of two enalapril formulations in the treatment of hypertension in Addis Ababa, Ethiopia: study protocol for a randomized controlled trial

Table 2 Dose adjustment plan

Change in average BP	Initial dose	Dose adjustment	Maximum
< + 5 mmHg	Current dose	No adjustment – complete the cycle	20 mg
≥ + 5 mmHg	Current dose	Current dose + 5 mg	25 mg
≤ 5 mmHg fall	Current dose	No adjustment – complete the cycle	20 mg
≥ 5 mmHg fall and asymptomatic	Current dose	No adjustment – complete the cycle	20 mg
≥ − 5 mmHg and symptomatic	Current dose	Current dose − 5 mg	15 mg

ISSN: 1745-6215