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Table 1 Relationship between neutrophil count and coronary flow reserve based on previous studies

From: CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial

Study

Neutrophil count

Echo-based CFR (mean ± SE)

CFR increase

SD of PET-MPR [22]

Patients required (p < 0.05, 80% power)

Stable CAD cohort

 

5.8

2.10 ± 0.19

 

0.36

 
 

4.6

2.35 ± 0.12

10.6%

0.36

33

 

4.2

2.43 ± 0.11

13.5%

0.36

19

Post-MI cohort

 

5.8

2.45 ± 0.07

 

0.36

 
 

4.6

2.64 ± 0.05

7.2%

0.36

57

 

4.2

2.70 ± 0.05

9.3%

0.36

33

  1. Abbreviations: CFR Coronary flow reserve, PET Positron emission tomography, MPR Myocardial perfusion reserve, CAD Coronary artery disease, MI Myocardial infarction
  2. The relationship between neutrophil count and echo-based CFR in both stable CAD and post-MI cohorts is shown. This demonstrates that lower neutrophil counts are associated with higher CFR