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Table 1 Relationship between neutrophil count and coronary flow reserve based on previous studies

From: CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial

Study Neutrophil count Echo-based CFR (mean ± SE) CFR increase SD of PET-MPR [22] Patients required (p < 0.05, 80% power)
Stable CAD cohort
  5.8 2.10 ± 0.19   0.36  
  4.6 2.35 ± 0.12 10.6% 0.36 33
  4.2 2.43 ± 0.11 13.5% 0.36 19
Post-MI cohort
  5.8 2.45 ± 0.07   0.36  
  4.6 2.64 ± 0.05 7.2% 0.36 57
  4.2 2.70 ± 0.05 9.3% 0.36 33
  1. Abbreviations: CFR Coronary flow reserve, PET Positron emission tomography, MPR Myocardial perfusion reserve, CAD Coronary artery disease, MI Myocardial infarction
  2. The relationship between neutrophil count and echo-based CFR in both stable CAD and post-MI cohorts is shown. This demonstrates that lower neutrophil counts are associated with higher CFR