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Table 3 Cox regression of PICC failure (n = 121)

From: Central venous Access device SeCurement And Dressing Effectiveness for peripherally inserted central catheters in adult acute hospital patients (CASCADE): a pilot randomised controlled trial

 

Univariable HR (95% CI)

Multivariable HR (95% CI)

Intervention (referent (ref) SPU + SSD + CHG):

 - PAL + CHG + Tape

1.60 (0.18–14.4)

4.17 (0.36–48.4)

 - CSD + CHG

1.06 (0.23–4.83)

0.64 (0.14–2.92)

 - TA + SPU

1.04 (0.23–4.67)

1.07 (0.24–4.83)

Age (one year older)

1.02 (0.97–1.06)

–

Female sex (ref. male)

0.15 (0.02–1.15)*

0.10 (0.01–0.87)**

Overweight/obese (ref. other)

1.70 (0.47–6.20)

–

Comorbidities (ref. up to 3)

3.37 (0.89–12.8)*

4.62 (1.04–20.4)**

Skin integrity fair/poor (ref. good)

2.00 (0.43–9.28)

–

Skin type brown (ref. white)

0.67 (0.14–3.12)

–

Diagnosis

 

–

 - oncology (ref. surgical)

1.50 (0.43–5.20)

–

 - medical (ref. surgical)

0.36 (0.04–3.09)

–

Gastrointestinal surgery (ref. other type)

0.90 (0.16–4.94)

–

Drain (ref. none)

2.10 (0.61–7.19)

–

Wound (ref. none)

0.91 (0.24–3.43)

–

Infection (ref. none)

1.14 (0.33–3.91)

–

IV therapy (ref. none)

a

–

Antibiotic therapy (ref. none)

0.75 (0.20–2.84)

–

U/S guided insertion with fluoroscopy (ref. U/S guided)

2.34 (0.71–7.70)*

b

Insertion on dominant side (ref. false)

1.07 (0.32–3.51)

–

Lumens (one more)

a

–

Subsequent device (ref. false)

2.68 (0.80–8.92)*

b

Device length (1 cm longer)

1.00 (0.91–1.11)

–

  1. Baseline observations were used; a = cannot be calculated; b = removed during variable selection at p ≥ 0.05; hyphen = not entered into the multivariate model
  2. PICC peripherally inserted central catheter, HR hazard ratio, CI confidence interval, SPU simple polyurethane dressing, SSD sutureless securement device, CHG chlorhexidine gluconate-impregnated discs, PAL polyurethane with absorbent lattice pad dressing, CSD combination securement dressing, TA tissue adhesive, U/S ultrasound
  3. *p value <0.20; **p value <0.05