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Fig. 1 | Trials

Fig. 1

From: Abiraterone acetate plus LHRH therapy versus abiraterone acetate while sparing LHRH therapy in patients with progressive, metastatic and chemotherapy-naïve, castration-resistant prostate cancer (SPARE): study protocol for a randomized controlled trial

Fig. 1

Schematic trial design from screening to final analysis. Patients will be randomized to receive abiraterone/prednisone ± continuation of LHRH therapy until radiographic progression or unequivocal clinical progression. Assessment of progression by computed tomography (CT)/magnetic resonance imaging (MRI) and bone scan will be repeated every 3 months. Bone Scan Index (BSI) will be analyzed at baseline and after 3 and 6 months. Hormone analysis includes FSH, LH, LHRH, DHEA, testosterone and dihydrotestosterone that will be measured at baseline, at months 1, 2 and 3, and every 3 months thereafter

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Trials

ISSN: 1745-6215