The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho: study protocol for a cluster randomized controlled trial

Table 1 Comparison of study arms

	Standard of care (SOC)	Community-based intervention (CBI)
Adult patients asked to bring child contacts to TB clinic for screening	X	X
Child contacts screened with symptom questionnaire	X	X
IPT offered to eligible child contacts	X	X
Monthly IPT visits	X	X
HIV testing encouraged for eligible child contacts	X	X
Active community contact tracing		X
Community-based health education using study brochure		X
Child screening and IPT provision according to clinical algorithm		X
Nurse training and ongoing mentorship		X
Health education for caregivers using treatment literacy curriculum		X
Active tracking of IPT provision		X
Consistent community support via VHW		X
Social support and navigation by VHW		X
SMS medication and appointment reminder messages		X
Review of IPT monitoring data at quarterly multidisciplinary team meetings		X

TB tuberculosis, IPT Isoniazid preventive therapy, VHW village health worker, SMS short message service

ISSN: 1745-6215