Table 4 The association of selected demographic and clinical variables with the three factors as analyzed via multiple linear regression – mean score and standard deviation (SD) for each demographic and clinical variable and factor, where with factor 1, scores near 100 mean complete knowledge of clinical trials (CTs); with factor 2, scores close to 100 indicate commitment to participating; and factor 3 indicates high therapeutic misconception (* = statistically significant p value < 0.05)
Variables | F1: Knowledge of CTs | F2: Willingness | F3: Therapeutic misconception | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean score | SD | β-coef. | p value | Mean score | SD | β-coef. | p value | Mean score | SD | β-coef. | p value | ||
Age band (years) | n | 0.092 | 0.552 | 0.004* | |||||||||
≤ 59 (ref.) | 67 | 79.3 | 10.5 | 60.3 | 21.9 | 48.4 | 18.0 | ||||||
60–69 | 278 | 78.0 | 11.8 | –1.5 | 0.381 | 61.9 | 19.7 | – 2.1 | 0.472 | 53.1 | 17.1 | 4.4 | 0.076 |
70–79 | 261 | 76.4 | 12.2 | –2.5 | 0.147 | 59.5 | 20.8 | – 0.2 | 0.946 | 56.4 | 18.4 | 6.5 | 0.011 |
≥ 80 | 65 | 74.3 | 10.5 | −5.2 | 0.021 | 59.7 | 19.3 | – 0.7 | 0.868 | 61.4 | 15.3 | 11.4 | 0.001* |
Gender | 0.556 | <0.001* | 0.187 | ||||||||||
Female (ref.) | 298 | 77.1 | 11.8 | 57.2 | 19.8 | 54.4 | 18.7 | ||||||
Male | 374 | 77.0 | 12.4 | 0.5 | 0.556 | 63.2 | 20.6 | 6 | <0.001* | 54.9 | 17.3 | 1.8 | 0.19 |
Education | <0.001* | 0.111 | <0.001* | ||||||||||
Basic education (ref.) | 199 | 73.7 | 12.5 | 57.4 | 20.1 | 59.4 | 18.5 | ||||||
Vocational training | 338 | 77.8 | 11.7 | 3.2 | 0.003* | 61.6 | 20.9 | 3.3 | 0.083 | 55.2 | 16.6 | – 3.5 | 0.027* |
Academic degree | 132 | 79.9 | 11.4 | 6.1 | <0.001* | 62.6 | 19.4 | 4.5 | 0.058 | 45.7 | 17.3 | – 12.9 | <0.001* |
Work ability | 0.015* | 0.477 | 0.866 | ||||||||||
Able to work (ref.) | 26 | 77.9 | 12.0 | 58.7 | 22.3 | 50.3 | 20.1 | ||||||
On sick leave | 10 | 71.3 | 11.4 | −9.9 | 0.04* | 53.9 | 11.4 | −9.5 | 0.261 | 49.6 | 18.3 | 3.8 | 0.594 |
Retired | 635 | 77.1 | 12.3 | 2.2 | 0.396 | 60.6 | 20.5 | −0.5 | 0.907 | 54.9 | 17.8 | – 1.2 | 0.761 |
Duration of Parkinson’s disease | 0.419 | 0.733 | 0.168 | ||||||||||
0–4 years (ref.) | 221 | 77.6 | 11.8 | 60.0 | 20.1 | 54.2 | 17.0 | ||||||
5–9 years | 238 | 76.5 | 11.7 | –1.2 | 0.304 | 61.5 | 19.4 | 1.2 | 0.547 | 56.0 | 18.3 | 2.0 | 0.253 |
≥ 10 years | 202 | 77.9 | 11.8 | 0.2 | 0.902 | 60.2 | 21.7 | – 0.2 | 0.928 | 53.3 | 18.3 | −1.1 | 0.531 |
Parkinson’s disease medication | 0.600 | 0.502 | 0.022* | ||||||||||
1 drug (ref.) | 118 | 75.0 | 13.1 | 57.4 | 19.7 | 59.3 | 18.7 | ||||||
2 drugs | 202 | 77.2 | 10.9 | 1.4 | 0.319 | 60.5 | 21.4 | 1.5 | 0.538 | 54.8 | 17.4 | −4.7 | 0.023* |
3 or more drugs | 346 | 77.6 | 12.4 | 0.8 | 0.571 | 61.4 | 20.0 | 2.8 | 0.251 | 53.0 | 17.7 | −5.5 | 0.007* |
Other chronic disease(s) | 0.285 | 0.860 | 0.168 | ||||||||||
Yes | 428 | 78.0 | 11.5 | −1.0 | 0.285 | 60.9 | 20.3 | 0.3 | 0.86 | 55.0 | 16.8 | −2.0 | 0.168 |
No (ref.) | 249 | 76.5 | 12.4 | 60.3 | 20.5 | 54.4 | 18.5 | ||||||