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Table 4 The association of selected demographic and clinical variables with the three factors as analyzed via multiple linear regression – mean score and standard deviation (SD) for each demographic and clinical variable and factor, where with factor 1, scores near 100 mean complete knowledge of clinical trials (CTs); with factor 2, scores close to 100 indicate commitment to participating; and factor 3 indicates high therapeutic misconception (* = statistically significant p value < 0.05)

From: Clinical features of Parkinson’s disease patients are associated with therapeutic misconception and willingness to participate in clinical trials

Variables F1: Knowledge of CTs F2: Willingness F3: Therapeutic misconception
Mean score SD β-coef. p value Mean score SD β-coef. p value Mean score SD β-coef. p value
Age band (years) n     0.092     0.552     0.004*
  ≤ 59 (ref.) 67 79.3 10.5    60.3 21.9    48.4 18.0   
 60–69 278 78.0 11.8 –1.5 0.381 61.9 19.7 – 2.1 0.472 53.1 17.1 4.4 0.076
 70–79 261 76.4 12.2 –2.5 0.147 59.5 20.8 – 0.2 0.946 56.4 18.4 6.5 0.011
  ≥ 80 65 74.3 10.5 −5.2 0.021 59.7 19.3 – 0.7 0.868 61.4 15.3 11.4 0.001*
Gender      0.556     <0.001*     0.187
 Female (ref.) 298 77.1 11.8    57.2 19.8    54.4 18.7   
 Male 374 77.0 12.4 0.5 0.556 63.2 20.6 6 <0.001* 54.9 17.3 1.8 0.19
Education      <0.001*     0.111     <0.001*
 Basic education (ref.) 199 73.7 12.5    57.4 20.1    59.4 18.5   
 Vocational training 338 77.8 11.7 3.2 0.003* 61.6 20.9 3.3 0.083 55.2 16.6 – 3.5 0.027*
 Academic degree 132 79.9 11.4 6.1 <0.001* 62.6 19.4 4.5 0.058 45.7 17.3 – 12.9 <0.001*
Work ability      0.015*     0.477     0.866
 Able to work (ref.) 26 77.9 12.0    58.7 22.3    50.3 20.1   
 On sick leave 10 71.3 11.4 −9.9 0.04* 53.9 11.4 −9.5 0.261 49.6 18.3 3.8 0.594
 Retired 635 77.1 12.3 2.2 0.396 60.6 20.5 −0.5 0.907 54.9 17.8 – 1.2 0.761
Duration of Parkinson’s disease      0.419     0.733     0.168
 0–4 years (ref.) 221 77.6 11.8    60.0 20.1    54.2 17.0   
 5–9 years 238 76.5 11.7 –1.2 0.304 61.5 19.4 1.2 0.547 56.0 18.3 2.0 0.253
  ≥ 10 years 202 77.9 11.8 0.2 0.902 60.2 21.7 – 0.2 0.928 53.3 18.3 −1.1 0.531
Parkinson’s disease medication      0.600     0.502     0.022*
 1 drug (ref.) 118 75.0 13.1    57.4 19.7    59.3 18.7   
 2 drugs 202 77.2 10.9 1.4 0.319 60.5 21.4 1.5 0.538 54.8 17.4 −4.7 0.023*
 3 or more drugs 346 77.6 12.4 0.8 0.571 61.4 20.0 2.8 0.251 53.0 17.7 −5.5 0.007*
Other chronic disease(s)      0.285     0.860     0.168
 Yes 428 78.0 11.5 −1.0 0.285 60.9 20.3 0.3 0.86 55.0 16.8 −2.0 0.168
 No (ref.) 249 76.5 12.4    60.3 20.5    54.4 18.5