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Table 1 Study eligibility criteria

From: SAFE (Sarpogrelate Anplone in Femoro-popliteal artery intervention Efficacy) study: study protocol for a randomized controlled trial

Inclusion criteria

 

 Age > 18 years

 

 Angiographically confirmed significant FP stenosis or occlusion by atherosclerosis

 

 Successful FP intervention (residual stenosis < 30% after EVT)

 

 Without significant residual inflow disease; intact iliac artery inflow (with or without intervention of iliac or below knee arteries)

 

 Patent outflow status; at least one arterial runoff in BTK

 

 All kind of FP interventions including POBA, stent, DCB, DES for TASC A ~ D

 

Exclusion criteria

 

 At risk of hemorrhage, bleeding tendency, or thrombophilia

 

 Acute limb ischemia / inflammatory arterial disease

 

 Contraindication or allergic to ASA, clopidogrel, Anplone

 

 Medication of warfarin

 

 Pregnancy, hepatic dysfunction, thrombocytopenia

 

 Previous FP bypass surgery or intervention

 

 Impossible to stop clopidogrel before EVT

 

 Unable to give informed consent.

 
  1. FP femoro-popliteal, EVT endovascular treatment, BTK below-the-knee, POBA plain old balloon angioplasty, DCB drug-coated balloon, DES drug-eluting stent, TASC The Trans-Atlantic Inter-Society Consensus, ASA aspirin