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Table 3 Eligibility criteria

From: General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial

Inclusion criteria Exclusion criteria
Has a current acute exacerbation (presenting with at least 1 of the following: increased dyspnoea, increased sputum volume, increased sputum purulence) that has lasted for at least 24 h and no longer than 21 days The responsible GP feels urgent referral to hospital is necessary
Diagnosis of COPD in clinical record/on COPD practice register Severe illness (e.g. suspected pneumonia, tachypnoea > 30 breaths/min, respiratory failure)
Age 40 years or more Concurrent infection at another site (e.g. UTI, cellulitis) that is likely to produce a systemic response
Able to provide informed consent Past history of respiratory failure or mechanical ventilation
Patient should be able to provide the primary outcome data at 2 and 4 weeks within the expected windows Currently taking antibiotics or has taken antibiotics for this acute exacerbation of COPD
  Active inflammatory condition (e.g. flare up of rheumatoid arthritis, gout or polymyalgia rheumatica)
  Has cystic fibrosis, a current tracheostomy or bronchiectasis
  Immunocompromised (e.g. AIDS, taking systemic immunosuppressive therapy or receiving anti-cancer radiotherapy or chemotherapy)
  Currently pregnant
  Previously been recruited into the PACE study
  1. COPD chronic obstructive pulmonary disease, GP general practitioner, UTI urinary tract infection