Skip to content


Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial

  • Janine Bates1Email authorView ORCID ID profile,
  • Nick A. Francis2,
  • Patrick White3,
  • David Gillespie1,
  • Emma Thomas-Jones1,
  • Rachel Breen1,
  • Nigel Kirby1,
  • Kerry Hood1,
  • Micaela Gal2,
  • Rhiannon Phillips2,
  • Gurudutt Naik2,
  • Jochen Cals4,
  • Carl Llor5,
  • Hasse Melbye6,
  • Mandy Wootton7,
  • Evgenia Riga8,
  • Ann Cochrane3,
  • Robin Howe7,
  • Deborah Fitzsimmons9,
  • Bernadette Sewell9,
  • Mohammed Fasihul Alam10 and
  • Christopher C. Butler8

Received: 7 February 2017

Accepted: 14 August 2017

Published: 29 September 2017

Back to article

Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
7 Feb 2017 Submitted Original manuscript
27 May 2017 Reviewed Reviewer Report - Xinxing Lai
10 Aug 2017 Author responded Author comments - Janine Bates
Resubmission - Version 2
10 Aug 2017 Submitted Manuscript version 2
14 Aug 2017 Editorially accepted
29 Sep 2017 Article published 10.1186/s13063-017-2144-8

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

South East Wales Trials Unit, Centre for Trials Research, Cardiff University, Cardiff, UK
Department of Population Medicine, Cardiff University School of Medicine, Cardiff, UK
Department of Primary Care and Public Health Sciences, King’s College London, London, UK
Department of General Practice, Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands
University Institute in Primary Care Research Jordi Gol, Primary Healthcare Centre Via Roma, Barcelona, Spain
Institute of Community Medicine, University of Tromsø, Tromsø, Norway
Specialist Antimicrobial Chemotherapy Unit, University Hospital of Wales, Cardiff, UK
The Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
Swansea Centre for Health Economics, College of Human and Health Sciences, Room 216, Vivian Tower, Swansea University, Swansea, UK
Public Health Department, College of Health Sciences, Qatar University, Doha, Qatar