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Table 3 Mean eGFR at baseline versus follow-up (ml/min/1.73 m2)

From: A randomized, multi-center, prospective study comparing best medical treatment versus best medical treatment plus renal artery stenting in patients with hemodynamically relevant atherosclerotic renal artery stenosis (RADAR) – one-year results of a pre-maturely terminated study

  ITT unpaired data ITT paired data   Per-protocol paired data  
Stent BMT P value Stent BMT P value Stent BMT P value
Baseline 52.6 ± 22.1 55.9 ± 21.0 0.589 57.0 ± 20.8 60.8 ± 21.3 0.725 57.0 ± 20.8 61.4 ± 21.7 0.653
2 month 55.4 ± 20.1 55.9 ± 22.2 0.940 57.4 ± 20.9 58.8 ± 21.2 0.967 57.4 ± 20.9 58.7 ± 21.7 0.983
6 month 59.1 ± 26.6 56.7 ± 24.5 0.800 57.7 ± 22.2 60.1 ± 22.9 0.877 57.7 ± 22.2 60.2 ± 23.5 0.872
12 month 59.8 ± 22.4 62.3 ± 21.6 0.767 60.1 ± 24.1 63.1 ± 21.8 0.649 60.1 ± 24.1 63.3 ± 22.3 0.700
Change baseline–2 months 0.5 ± 9.5 −2.2 ± 10.1 0.277 0.4 ± 9.5 − 2.0 ± 10.3 0.844 0.4 ± 9.5 − 2.8 ± 9.9 0.660
Change baseline − 6 months 1.3 ± 12.5 − 0.6 ± 14.5 0.549 0.7 ± 12.0 − 0.7 ± 15.3 0.656 0.7 ± 12.0 − 1.2 ± 15.5 0.507
Change baseline–12 months 4.3 ± 15.4 3.0 ± 14.9 > 0.999 3.1 ± 15.3 2.3 ± 14.9 0.812 3.1 ± 15.3 1.9 ± 15.1 0.906
  1. The ITT population includes the three BMT patients receiving bailout stenting prior to 6 months and includes patients receiving bailout stenting after 6 months until they received stenting. The per-protocol analysis excludes patients with bailout stenting prior to 6 months and 2 patients in the stent group who received a non-study stent. Unpaired data were available at baseline, 2, 6, and 12 months in 70, 67, 61, and 54 patients, respectively and data were available on change at 2, 6, and 12 months compared to baseline in 61, 58, and 51 patients, respectively. Intention-to-treat (ITT) paired data were available in 28 patients in the stent group and in 23 patients in the BMT group, for the per protocol analysis in 26 and 21 patients, respectively. Unpaired data at respective time points refer to the data available and change refers to change in the data based on paired datasets. Paired data means that datasets were available at all time points. BMT best medical treatment, eGFR estimated glomerular filtration rate