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Table 3 Mean eGFR at baseline versus follow-up (ml/min/1.73 m2)

From: A randomized, multi-center, prospective study comparing best medical treatment versus best medical treatment plus renal artery stenting in patients with hemodynamically relevant atherosclerotic renal artery stenosis (RADAR) – one-year results of a pre-maturely terminated study

 

ITT unpaired data

ITT paired data

 

Per-protocol paired data

 

Stent

BMT

P value

Stent

BMT

P value

Stent

BMT

P value

Baseline

52.6 ± 22.1

55.9 ± 21.0

0.589

57.0 ± 20.8

60.8 ± 21.3

0.725

57.0 ± 20.8

61.4 ± 21.7

0.653

2 month

55.4 ± 20.1

55.9 ± 22.2

0.940

57.4 ± 20.9

58.8 ± 21.2

0.967

57.4 ± 20.9

58.7 ± 21.7

0.983

6 month

59.1 ± 26.6

56.7 ± 24.5

0.800

57.7 ± 22.2

60.1 ± 22.9

0.877

57.7 ± 22.2

60.2 ± 23.5

0.872

12 month

59.8 ± 22.4

62.3 ± 21.6

0.767

60.1 ± 24.1

63.1 ± 21.8

0.649

60.1 ± 24.1

63.3 ± 22.3

0.700

Change baseline–2 months

0.5 ± 9.5

−2.2 ± 10.1

0.277

0.4 ± 9.5

− 2.0 ± 10.3

0.844

0.4 ± 9.5

− 2.8 ± 9.9

0.660

Change baseline − 6 months

1.3 ± 12.5

− 0.6 ± 14.5

0.549

0.7 ± 12.0

− 0.7 ± 15.3

0.656

0.7 ± 12.0

− 1.2 ± 15.5

0.507

Change baseline–12 months

4.3 ± 15.4

3.0 ± 14.9

> 0.999

3.1 ± 15.3

2.3 ± 14.9

0.812

3.1 ± 15.3

1.9 ± 15.1

0.906

  1. The ITT population includes the three BMT patients receiving bailout stenting prior to 6 months and includes patients receiving bailout stenting after 6 months until they received stenting. The per-protocol analysis excludes patients with bailout stenting prior to 6 months and 2 patients in the stent group who received a non-study stent. Unpaired data were available at baseline, 2, 6, and 12 months in 70, 67, 61, and 54 patients, respectively and data were available on change at 2, 6, and 12 months compared to baseline in 61, 58, and 51 patients, respectively. Intention-to-treat (ITT) paired data were available in 28 patients in the stent group and in 23 patients in the BMT group, for the per protocol analysis in 26 and 21 patients, respectively. Unpaired data at respective time points refer to the data available and change refers to change in the data based on paired datasets. Paired data means that datasets were available at all time points. BMT best medical treatment, eGFR estimated glomerular filtration rate
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Trials

ISSN: 1745-6215