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Table 2 Number of individuals and number of clusters required for a cluster randomised crossover (CRXO), cluster randomised controlled trial (CRCT) and individually randomised controlled trial (IRCT) trial with ρ = 0.038 for all designs and specified η for CRXO design

From: Understanding the cluster randomised crossover design: a graphical illustration of the components of variation and a sample size tutorial

  Number of required individuals Number of required ICUs
ρ = 0.038, η = 0.032 10,564 27
ρ = 0.038, η = 0.010 30,433 77
CRCT 39,065 196
IRCT 4345 22
  1. ICU intensive care unit