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Core outcome set (COS)
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An agreed minimum set of outcomes that should be measured and reported in all trials in a specific condition [11]
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Outcome
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A unique endpoint which attempts to describe health-related changes that occur secondary to a therapeutic intervention, e.g. hospital-acquired pneumonia
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Outcome domain
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A collection of ‘outcomes’ which share common features, e.g. the outcome domain ‘respiratory complications’ would include outcomes such as ‘pleural effusion’, ‘hospital-acquired pneumonia’ and ‘atelectasis’
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Outcome measurement instrument (OMI)
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A method or tool used to measure an ‘outcome’ or an ‘outcome domain’
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Outcome measurement instrument set
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A collection of OMIs which are used to measure outcome domains in a COS
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