| First stage |  | Simulations in which arm was dropped at interimc | Assumed |
---|---|---|---|---|
Study arm | aProportion | SDb | Proportion | Proportiond |
1 Standard of care | 0.250 | 0.048 | NA | 0.250 |
2 Intervention | 0.291 | 0.055 | 0.441 | 0.290 |
3 Intervention | 0.299 | 0.058 | 0.336 | 0.300 |
4 Intervention | 0.310 | 0.059 | 0.215 | 0.310 |
5 Intervention | 0.321 | 0.061 | 0.114 | 0.320 |
6 Intervention | 0.400 | 0.078 | 0.000 | 0.400 |