Table 3 Primary outcome Combined adherence endpoint

Domain

Combined medication adherence

Specific measurement variable

Adherence status (dichotomous)

adherent: MMAS-8 score ≥6 and pill count rate ≥80%

non-adherent: MMAS-8 score <6 and/or pill count rate <80%

Analysis Metric

Final value (Visit 2)

Method of aggregation

Proportion of adherent patients (%)

Time point of measurement

At Visit 2 (follow-up visit after 3 months of intervention period)