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Fig. 8 | Trials

Fig. 8

From: A comparison of approaches for adjudicating outcomes in clinical trials

Fig. 8

Site vs. central assessors; site assessors have lower false-negative rates, central assessors have lower false-positive rates. This figure shows the association between different adjudication approaches and power. The intraclass correlation coefficient (ICC) represents the degree of correlation between different assessors, with a value of zero indicating no more agreement between assessors than would be expected by chance, and a value of one indicating perfect agreement between assessors. Site assessor: 20% false-positive rate, 10% false-negative rate. Central assessor: 10% false-positive rate, 20% false-negative rate. With three assessors (3 CA, 1 SA + 2 CA), the outcome was adjudicated based on the majority (i.e. if two or more of the assessors adjudicated an event, the outcome was classified as an event, and vice versa). CA, central assessor; SA, site assessor

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